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Streptomyces produce many of our clinically-relevant antibiotics, and genome sequences show potential for other cryptic genes that may lead to the discovery of new compounds. A new Antimicrobial Agents and Chemotherapy report finds a single mutation leads to both increased resistance to one antibiotic and increased production of another. This type of mutation may help scientists unlock cryptic...
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Unlocking cryptic Streptomyces genes in the search for potential new antibiotics

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The ASM Clinical Virology Sympsoium is the perfect opportunity for you to share and present your research and recent discoveries in clinical virology with your peers from across the globe.

Don't miss this great opportunity. Submit your abstract, apply for a travel award, and register to join us for #ASMCVS today! [ Bit.ly Link ]
Stay tuned for mSphereDirect, a faster way to publish your science that puts you in control. For more information Sign Up [ Bit.ly Link ] #mSphere
Your cutting-edge research and recent discoveries allows #ASMicrobe to showcase the best of the microbial sciences. Submit an abstract today to share your knowledge and expertise with your peers from around the world [ Bit.ly Link ]

Don't Forget! Travel award applications are being accepted until January 9, 2017. Be sure to apply after you submit your abstract! [ Bit.ly Link ]
Do you remember taking your introductory microbiology lab course? Most labs have used (and many still do use) traditional techniques such as differential media and biochemical assays to test a given unknown. We spoke with Dr. Mary Miller, who changed her course by implementing the Small World Initiative. The SWI allows students to practice these same fundamental techniques while performing...
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Basing a curriculum on discovery-based research

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TWiV 418: A new animal model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the mouse gene encoding an ortholog of the virus receptor. [ Bit.ly Link ] #MERS #viruses #microbiology #CRISPR
ASM’s December Hot Topic discussion, “Competency Assessment in Microbiology” is presented by Susan E. Richardson, M.D., FRCPC, Hospital for Sick Children.

Dr. Richardson’s presentation has been posted to [ Bit.ly Link ]. You are encouraged to log in and view it at your convenience. You can submit questions for Dr. Richardson until Friday, December 9, 2016. The discussion’s questions and...
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Hot Topics

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Microbiology Mondays: Doing research in the era of ‘big data’ means there are many data sets that can be reanalyzed for new purposes. A new report in mSphere analyzed 1700 E. coli genomes, in combination with proteomics, to identify surface-exposed or secreted proteins. The scientific team used this analysis to pinpoint novel antigens for vaccine development. They identified the protein YncE...
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When you gain weight, you gain changes in microbes and metabolism too. But they’re harder to get rid of than those last five pounds ever were.

The holiday season is upon us, and we all know what that means: any progress made toward that perfect beach bod over the summer months comes crashing down in the face of Thanksgiving leftovers. You triumphantly lose five pounds in two days, only to...
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High-Fat Holiday Food and the Yo-Yo diet: Are microbes to blame for your weight re-gain?

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#POTD from Scott Chimileski, a member of our blogger team.

FASEB 2016 #BioArt Winner

This dime-sized biofilm, however, was formed by the opportunistic pathogen Pseudomonas aeruginosa. Under the right conditions, this bacterium can infect wounds caused by severe burns. The bacteria release a variety of materials to form an extracellular matrix (stained red). The matrix holds the biofilm...
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Basic research is very important to understand the HIV replication cycle and identify new antiviral targets. A recent mBio report describes a mutation in the HIV-encoded Tat gene, called Tat nullbasic, that shuts down HIV-1 transcription in cells. Cells infected with this mutant virus (called NB-ZSG1 in the above figure) showed no detectable HIV-1 replication. Further studies could lead to...
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Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein

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"Clinical microbiology laboratories are on the front lines of the fight against infectious diseases such as HIV/AIDS and related opportunistic infections, and in places like Ethiopia, the need for high-quality systems and training is imperative." #WorldAIDSDay2016

ASM Delivers "Gift of Knowledge" to Ethiopia with Microbiology Mentoring Program

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The 2016 World AIDS Day theme is 'On the Fast Track to End AIDS." The microbial science and ASM have much to offer in helping the world on that track. ASM CEO Stefano Bertuzzi explains these roles in his latest bLog Phase post: [ Bit.ly Link ]

World AIDS Day 2016

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Monitoring of HIV-1 RNA, or viral load, in patients on antiretroviral therapy is important, but there are multiple impediments to testing in resource-constrained settings. A new Journal of Clinical Microbiology report describes an accurate point-of-care HIV-1 viral load test that could alleviate these challenges. The test is accurate at both low and high viral loads (shown here) and is a...
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