A new therapy to treat fatty liver disease, based on the elimination of ‘old’ (so-called senescent) liver cells, is demonstrated in mouse models. The study finds that senescent liver cells promote the accumulation of fat in the liver and shows that drugs that selectively kill senescent cells can reduce liver disease.
A new therapy to treat fatty liver disease based on the elimination

Cellular senescence drives age-dependent hepatic steatosis

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Joel Adam
Building on insights from an HIV vaccine regimen in humans that had partial success during a phase 3 clinical trial, researchers have used a more-is-better approach in monkeys that appeared to improve vaccine protection from an HIV-like virus. The study increased the level of protection to 55% by using a five-part vaccine.
Building on insights from an HIV vaccine regimen in humans that had

Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

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A study has shown that metastatic breast cancer cells signal neighbouring cells in ways that allow otherwise anchored cells to metastasize. The work pinpoints a promising link in the chain of signaling that, when broken, could reduce the metastatic potential of the disease.
A study has shown that metastatic breast cancer cells signal neighbouring cells

EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

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Researchers have found a direct window into the brain systems involved in making every day decisions based on preference. The study offers crucial insight into the neural mechanisms underlying our decision-making process, opening up new avenues for the investigation of preference-based choices in humans.
Researchers have found a direct window into the brain systems involved in

Neural correlates of evidence accumulation during value-based decisions revealed via simultaneous EEG-fMRI

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Ambiguity of Paris Agreement pledges means that estimates of global greenhouse gas emissions by 2030 may vary by about 30% according to an analysis. The study indicates that these uncertainties could be reduced by including simple clarifications of the contributions pledged by individual countries.
Ambiguity of Paris Agreement pledges means that estimates of global greenhouse gas

Understanding the origin of Paris Agreement emission uncertainties

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Alfred Chin
April temperatures in mainland Southeast Asia reach record-breaking highs following El Niño years, according to a study. The research also suggests that global warming has increased the frequency of such extremes.
April temperatures in mainland Southeast Asia reach recordbreaking highs followi

Extreme temperatures in Southeast Asia caused by El Niño and worsened by global warming

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Remedying muscular disorders means figuring out how to coax muscle stem cells to fuse together and form functioning skeletal muscle tissues. Researchers have identified a new gene essential to this process, shedding new light on possible new therapeutic strategies.
Remedying muscular disorders means figuring out how to coax muscle stem cells

Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development

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Nature Communications
Nanoparticles that talk to each other using chemical messengers are described in a study. This achievement may inspire future development of nanoscale computing and information processing.
Nanoparticles that talk to each other using chemical messengers are described in

Interactive models of communication at the nanoscale using nanoparticles that talk to one another

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Mónica Barradas
Hominin evolution and dispersal patterns in the East African Rift System were controlled by groundwater availability according to a new study. The research shows that groundwater acted as a buffer to climate variability in the region by providing a source of fresh water in the form of natural springs.
Hominin evolution and dispersal patterns in the East African Rift System were

Modelling the role of groundwater hydro-refugia in East African hominin evolution and dispersal

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In rats, the susceptibility of male offspring to develop addiction towards cocaine is correlated with the father’s level of motivation to seek cocaine. The findings link the behaviour to structural DNA methylation changes, which may contribute to the heritability of tendencies to develop drug addiction.
In rats the susceptibility of male offspring to develop addiction towards cocaine

Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour

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The genetic composition of ancient Egyptian populations is revealed in an analysis of ancient mummy DNA. The samples span a period of around 1,300 years and suggest that ancient Egyptians shared more ancestry with Near Easterners than modern Egyptians.
The genetic composition of ancient Egyptian populations is revealed in an analysis

Ancient Egyptian mummy genomes suggest an increase of Sub-Saharan African ancestry in post-Roman periods

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When humans see the beginning of an expected sequence, their brains automatically play the whole sequence in “fast-forward”, according to a study. Researchers find that the pre-play might constitute an automatic prediction mechanism for temporal sequences in the visual cortex.
When humans see the beginning of an expected sequence their brains automatically

Time-compressed preplay of anticipated events in human primary visual cortex

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Henrik Pelling
A soft, gripping device that can sense and pick up objects, mimicking the Venus flytrap, is described. The simple robot is capable of identifying targets and may be ideal for autonomous handling of delicate objects. [ Nature.com Link ]
Our latest Hero Image: Two-dimensional materials are receiving increasing interest as they could pave the way to a paradigm shift in nano-electronics. Here, the authors demonstrate a 1-bit implementation of a microprocessor consisting of 115 transistors, using atomically thin MoS2.

Read more at: [ Nature.com Link ]
Our latest Hero Image Twodimensional materials are receiving increasing interest as they
According to a study, the economic status of an individual can be mathematically predicted by analysing their position within their social network. This method for determining the financial status within a population could be used for targeted social campaigns.
According to a study the economic status of an individual can be

Inferring personal economic status from social network location

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Researchers demonstrate an advance for the field of fertility preservation by being the first reported functional ovarian implant in a mouse model using 3D printing.
Researchers demonstrate an advance for the field of fertility preservation by being

A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice

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Maintaining the supply of a molecule that helps to nourish cartilage prevented osteoarthritis in animal models. The study provides evidence that adenosine, a biochemical at the heart of human cellular function, plays another crucial role in controlling the number of healthy chondrocytes, the cells that produce cartilage.
Maintaining the supply of a molecule that helps to nourish cartilage prevented

Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression

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Research has demonstrated a mechanism that causes new solar cells to break down in air. Light-absorbing materials called organic lead halide perovskites are used in new types of solar cells that have shown great promise, as they are more flexible and cheaper to manufacture than traditional solar cells constructed of silicon.
Research has demonstrated a mechanism that causes new solar cells to break

Fast oxygen diffusion and iodide defects mediate oxygen-induced degradation of perovskite solar cells

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Evidence for life discovered in 3.48 billion-year-old hot spring deposits in Australia is presented in a study. The findings extend the known geological record of inhabited terrestrial hot springs on Earth by around 3 billion years, and represent some of the earliest evidence for life on Earth.
Evidence for life discovered in 348 billionyearold hot spring deposits in Australia

Earliest signs of life on land preserved in ca. 3.5 Ga hot spring deposits

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A method for the remote detection of radioactive material is demonstrated in a study. Remote detection tools could be used to aid the safe handling of radioactive substances and may have potential uses in dealing with nuclear hazards, including accidents at nuclear power plants and the detection of nuclear weapons.
A method for the remote detection of radioactive material is demonstrated in

Remote detection of radioactive material using high-power pulsed electromagnetic radiation

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