Nature Reviews
03/25/2017 at 19:00. Facebook
BioPharma Dealmakers is a partnering supplement to Nature Biotechnology and Nature Reviews Drug Discovery featuring the latest on dealmaking opportunities and emerging therapeutic areas. Check out the latest issue for editorials on personalized cancer vaccines based on tumor-specific neoantigens, the expanding network of microbiome partnerships, and impending growth spurt of the dermatology...
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Nature Reviews
03/25/2017 at 16:00. Facebook
Biopharma Dealmakers: The drug delivery market continues to expand with innovations in biologics, as well as cell and gene therapies. Tune into learn about new technologies and their applications to oncology, CNS diseases and women’s health, and contribute your thoughts/questions during the live Q&A. [ Nature.com Link ]
Nature Reviews
03/25/2017 at 12:00. Facebook
Nature Reviews Genetics: The use of phylogenetics in cancer genomics is increasing owing to a growing appreciation of the importance of evolutionary theory to cancer progression. The authors provide guidance on the design and analysis of tumour phylogeny studies by surveying the range of phylogenetic methods and tools available to the cancer researcher and discussing their key applications and...
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Nature Reviews
03/24/2017 at 20:00. Facebook
Nature Reviews Drug Discovery: Genome editing has emerged as an attractive approach to therapeutically manipulate gene expression. Here, Anderson and colleagues provide an overview of genome-editing platforms, focusing on the methods and challenges of intracellular biomacromolecule delivery. Preclinical and clinical trials involving genome-editing technologies are also discussed. [ Nature.com...
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Nature Reviews
03/24/2017 at 19:17. Facebook
Chronic diseases associated with immunometabolic dysfunction are growing exponentially in all parts of the world. However, in the Asia Pacific Region the growth of some of these diseases is alarming. 

Inaugural Immunometabolism and Chronic Diseases Conference —

imcd.org.au
Nature Reviews
03/24/2017 at 19:12. Facebook
Nature Reviews Endocrinology: For decades, HbA1c has been regarded as the 'gold-standard' measure of glycaemic control. In this Review, Boris P. Kovatchev takes the unconventional view that HbA1c and glucose variability are expressions of the same underlying physiological process, evident on different timescales. [ Nature.com Link ] (£)
Nature Reviews
03/24/2017 at 14:04. Facebook
Nature Reviews Neurology Article series - Peripheral neuropathies : Gasparotti et al. provide an overview of new and emerging technologies for assessing a variety of peripheral neuropathies, including magnetic resonance neurography, diffusion tensor imaging and ultrasonography for large-fibre neuropathies, and corneal confocal microscopy, evoked potentials and microneurography for small-fibre...
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Nature Reviews
03/24/2017 at 12:00. Facebook
Nature Reviews Cancer: Insights into the effects of targeted therapies, conventional chemotherapy and radiation therapy, on the induction of antitumour immunity will help to advance the design of combination strategies that increase the rate of complete and durable clinical responses in patients. [ Nature.com Link ] (£)
Nature Reviews
03/23/2017 at 20:13. Facebook
Nature Reviews Disease Primers: Parkinson disease is a neurodegenerative disorder associated with dopamine depletion in the basal ganglia. This PrimeView focuses on the clinical course of Parkinson disease, in which non-motor symptoms, such as loss of smell and sleep disorders, can develop years before the onset of motor symptoms. [ Nature.com Link ]
Nature Reviews
03/23/2017 at 17:36. Facebook
Nature Reviews Rheumatology: The need for energy permeates every aspect of the life of immune cells, being especially important during periods of transition and differentiation such as during inflammation. In this Review, the authors provide an overview of the processes and pathways involved in immunometabolism. [ Nature.com Link ] (£)
Nature Reviews
03/23/2017 at 14:00. Facebook
Nature Reviews Cardiology: The role of hypertriglyceridaemia as a risk factor for coronary artery disease (CAD) is debated. In this Review, Reiner summarizes the causes of hypertriglyceridaemia, and discusses whether elevated blood triglyceride levels are an important and independent risk factor for CAD. Finally, current and emerging management options for hypertriglyceridaemia are detailed. [...
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Nature Reviews
03/23/2017 at 12:00. Facebook
Nature Reviews Neuroscience: Stroke survivors often adapt to the loss of upper-limb function by adopting compensatory strategies. Jones discusses evidence that these compensatory strategies may influence the neural remodelling processes that occur after the initial stroke and can have mixed effects on functional outcome of the paretic limb. [ Nature.com Link ] (£)
Nature Reviews
03/22/2017 at 20:00. Facebook
Nature Reviews Chemistry: The relative inertness of dinitrogen can be overcome by coordination to suitable organometallics. This Review explores the influence of coordination mode on the likelihood of functionalization and the nature of the products, which take the form of nitrogen-containing complexes and organics, as well as species such as NH3 and N2H4. [ Nature.com Link ]
Nature Reviews
03/22/2017 at 17:00. Facebook
Nature Reviews Gastroenterology and Hepatology Article Series - Techniques, technology & analysis: Various technologies and systems have been developed to improve adenoma detection rate during colonoscopy and thereby reduce colorectal cancer incidence. Here, Matsuda and colleagues discuss how add-on devices, colonoscope advances and image-enhanced endoscopy might assist in the detection of...
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Nature Reviews
03/21/2017 at 20:00. Facebook
Nature Reviews Urology: Nguyen and Thalmann review the benefits and disadvantages of the use of neoadjuvant chemotherapy in patients with bladder cancer, highlighting how clinical and molecular data can aid in personalizing treatment decisions, and discuss possible future application of targeted therapies and immune checkpoint inhibitors in this setting. [ Nature.com Link ] (£)
Nature Reviews
03/21/2017 at 17:00. Facebook
Nature Reviews Clinical Oncology: The costs of both newly approved, and established anticancer drugs have risen dramatically in the past decade, to the point where the costs of such treatments are becoming unsustainable. In this perspective, the authors outline the extent of this problem, and how it is likely to continue, while also suggesting measures that could be taken in future to address...
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Nature Reviews
03/21/2017 at 14:00. Facebook
Nature Reviews Materials: Atomic force microscopy (AFM)-based approaches enable the characterization and manipulation of biological and synthetic biointerfaces, including tissues, cells, membranes, proteins, nucleic acid and functional materials. In this Review, the advantages and limitations of imaging, sensing, parameterizing and designing biointerfaces using AFM techniques are discussed. [...
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Nature Reviews
03/21/2017 at 12:00. Facebook
Nature Reviews Immunology: The generation of a diverse T cell repertoire depends on heterogeneous populations of thymic epithelial cells (TECs). Here, the authors explain how different subsets of TECs support and coordinate different stages of T cell development to ensure the selection of a functional and self-tolerant T cell repertoire. [ Nature.com Link ] (£)
Nature Reviews
03/20/2017 at 20:00. Facebook
Nature Reviews Disease Primers : Alopecia areata is an autoimmune disorder characterized by transient hair loss. Severity can range from distinct patches to total hair loss. In this Primer, the authors describe the underlying pathophysiology of this complex polygenic disease, as well as the epidemiology, diagnosis and management. [ Nature.com Link ]
Nature Reviews
03/20/2017 at 17:00. Facebook
The pace of research in systemic lupus erythematosus has accelerated, and many new therapeutic agents are showing promise in early clinical trials. This collection from Nature Reviews Rheumatology, Nature Reviews Nephrology and Nature Reviews Disease Primers highlights progress in basic, translational and clinical research, including new insights into pathogenesis and identifying novel targets...
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Systemic lupus erythematosus

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