Nature Reviews
yesterday at 20:00. Facebook
Nature Reviews Chemistry : Atomic force microscopy (AFM) enables the imaging and manipulation of individual molecules at atomic resolution. This Review addresses experimental considerations, including operating modes and choices for tips and substrates. Examples are presented in which AFM is used to image molecules and induce bond formation or dissociation. [ Nature.com Link ]
Nature Reviews
yesterday at 17:00. Facebook
Nature Reviews Gastroenterology and Hepatology: Bidirectional gut–brain communications are proving key to both gastrointestinal and neurological diseases. This Review explores the role of the mucosal immune system as gatekeeper and master regulator of these brain–gut and gut–brain communications. [ Nature.com Link ] (£)
Nature Reviews
yesterday at 12:00. Facebook
Nature Reviews Molecular Cell Biology: Telomere shortening and loss of telomere protection can have a tumour-suppressive effect by mediating proliferation arrest. Ultimately, however, these processes can cause a state of extensive genome instability known as telomere crisis, which can facilitate tumorigenesis by causing oncogenic chromosomal rearrangements, including chromothripsis, kataegis...
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Nature Reviews
01/17/2017 at 20:00. Facebook
Nature Reviews Urology: Amongst the many causes of male-factor infertility, a diagnosed viral cause is a rather infrequent aetiological factor. However, a recent study has illustrated that Zika virus infections affect not only developing fetuses in pregnant women, but are also a threat to fertility in men. Whether this threat could be managed or mitigated remains uncertain....
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Nature Reviews
01/17/2017 at 17:00. Facebook
Nature Reviews Clinical Oncology: The interaction between radiotherapy and the host immune system has uncovered new mechanisms that can be exploited to improve the efficacy of radiotherapy. In this article, the authors highlight data providing new explanations for the success or failure of radiotherapy, and postulate, using radiation-induced tumour equilibrium (RITE) as an example, how the...
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Nature Reviews
01/17/2017 at 12:00. Facebook
Nature Reviews Materials: More than twenty 2D carbides, nitrides and carbonitrides of transition metals (MXenes) have been synthesized and studied, and dozens more predicted to exist. Highly electrically conductive MXenes show promise in electrical energy storage, electromagnetic interference shielding, electrocatalysis, plasmonics and other applications. [ Rdcu.be Link ]
Nature Reviews
01/16/2017 at 20:00. Facebook
Nature Reviews Disease Primers: PRIMER Viral infections during pregnancy and acquired genetic mutations account for the majority of cases of congenital hearing loss. Early detection of this chronic condition, through neonatal hearing screening programmes, greatly benefits the cognitive and social development of the child. [ Nature.com Link ]
Nature Reviews
01/16/2017 at 17:00. Facebook
Nature Reviews Nephrology: Decreasing susceptibility to tissue damage — a protective strategy known as tolerance — might be as important as infection resistance in determining outcomes in sepsis. Here, the authors discuss tolerance mechanisms that act in the kidney during sepsis, with a focus on the role of metabolic reprogramming. [ Nature.com Link ] (£)
Nature Reviews
01/16/2017 at 12:00. Facebook
Nature Reviews Microbiology: Bacteria have to overcome many obstacles to invade the meninges from the bloodstream. This Review considers how extracellular pathogens such as Neisseria meningitides and Streptococcus pneumoniae bypass the blood–brain barriers, the understanding of which may lead to improved methods for delivering drugs into the brain. [ Nature.com Link ] (£)
Nature Reviews
01/14/2017 at 12:00. Facebook
Nature Reviews Chemistry: Despite its relative weakness, the London dispersion force can strongly influence physical and chemical properties of molecules. This Review highlights how structure and reactivity of organometallic and inorganic molecules are greatly affected by the cumulative effect of this force. [ Nature.com Link ]
Nature Reviews
01/13/2017 at 20:00. Facebook
Nature Reviews Drug Discovery: Many organizations are attempting to harness emerging digital technologies and the surge in the amount of health-related data to drive advances in the development and use of medicines. Focusing on just a few well-proven and readily available strategies could enable such organizations to quickly realize greater value from data and digital technologies. [...
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Nature Reviews
01/13/2017 at 17:00. Facebook
Nature Reviews Nephrology: The kidney has a key role in maintaining glucose homeostasis and is the site of action of SGLT2 inhibitors, which enhance glucose excretion to reduce plasma glucose levels. Here, Ralph DeFronzo and colleagues examine the role of the kidney in regulating glucose reabsorption and the effect of SGLT2 inhibition on renal function, glucose homeostasis, and cardiovascular...
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Nature Reviews
01/13/2017 at 14:00. Facebook
Nature Reviews Neurology: Real-world observational studies have the potential to answer questions about multiple sclerosis (MS) treatment that randomized controlled trials cannot. Trojano and colleagues discuss the pitfalls and necessary safeguards in observational studies, and the insights that such studies have provided into treatment decisions for patients with MS. [ Nature.com Link ] (£)
Nature Reviews
01/12/2017 at 20:00. Facebook
Nature Reviews Disease Primers: Congenital hearing loss affects up to 3 per 1,000 children; it can severely impair speech and reading skills and emotional and cognitive development. This PrimeView highlights the importance of neonatal hearing screening programmes and early diagnosis in the management of this condition. [ Nature.com Link ]
Nature Reviews
01/12/2017 at 17:00. Facebook
Nature Reviews Rheumatology: Leptin is involved in regulating bone mass, basal metabolism and insulin secretion, among other processes. This Review explores the role of leptin in the immune system and metabolism, with particular emphasis on its effect on autoimmune and inflammatory rheumatic diseases. [ Nature.com Link ] (£)
Nature Reviews
01/12/2017 at 14:00. Facebook
Nature Reviews Cardiology: Left ventricular hypertrabeculation or noncompaction is a myocardial abnormality frequently associated with monogenic disorders, particularly neuromuscular disorders, or with chromosomal defects. The pathogenesis of this cardiomyopathy remains unknown, and the diagnostic criteria, prognosis, and optimal treatment are under debate. In this Review, Finsterer et al....
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Nature Reviews
01/12/2017 at 12:00. Facebook
Nature Reviews Neuroscience: Neuroimaging techniques are increasingly applied by the wider neuroscience community. However, problems such as low statistical power, flexibility in data analysis and software issues pose challenges to interpreting neuroimaging data in a meaningful and reliable way. Here, Poldrack et al. discuss these and other problems, and suggest solutions. [ Nature.com Link ] (£)
Nature Reviews Chemistry : Splitting water is an attractive means by which energy — either electrical and/or light — is stored and consumed on demand. Active and efficient catalysts for anodic and cathodic reactions often require precious metals. This Review covers base-metal catalysts that can afford high performance in a more sustainable and available manner. [ Nature.com Link ]
Nature Reviews Gastroenterology and Hepatology: Liver transplantation is the best option for patients with early-stage hepatocellular carcinoma. Here, the authors summarize the outcomes of liver transplantation, novel surgical techniques to increase the pool of donor livers for transplantation and the limitations of current priority policies. [ Nature.com Link ] (£)
Nature Reviews Chemistry is now live, check out the first issue! [ Nature.com Link ]