FBVideoDownloader.info is a facebook video downloader online, this tool helps you download facebook videos by grabs direct links to download and save for free
Nature Reviews
yesterday at 20:00. Facebook
Nature Reviews Drug Discovery: The success of mechanism-based drug discovery depends on the definition of the drug target, but targets are often poorly defined in the literature. Here, Overington and colleagues present a comprehensive map of the molecular targets of approved drugs, and explore aspects including the footprint of target classes across disease areas, the success of privileged...
View details ⇨
Nature Reviews
yesterday at 17:00. Facebook
Nature Reviews Endocrinology: Peroxisome proliferator-activated receptors (PPARs) are integrators of both inflammatory and metabolic signalling networks. In this Review, the authors provide a comprehensive overview of how PPARs contribute to the development of metabolic disorders and how pharmacologically targeting these pathways can be used to develop new therapeutics for such diseases. [...
View details ⇨
Nature Reviews
yesterday at 12:00. Facebook
Nature Reviews Cancer: This Opinion article discusses the various migration modes used by cancer cells in confining microenvironments and explains how understanding confined cancer cell motility in vivo through the application of engineered in vitro models could help to develop therapeutic approaches to prevent metastases. [ Nature.com Link ] (£)
Nature Reviews
12/01/2016 at 20:00. Facebook
Nature Reviews Disease Primers: This PrimeView on carcinogenic human papillomavirus (HPV) infection highlights the need for more reliable tests and strategies to predict cancer risk of a given HPV lesion. [ Nature.com Link ]
Nature Reviews
12/01/2016 at 14:00. Facebook
Nature Reviews Cardiology: Microorganisms that populate the human body have been shown to be involved in metabolic and cardiovascular disorders, but the precise mechanisms are not completely understood. In this Review, Lindskog Jonsson and Bäckhed describe the different pathways by which the gut microbiota might affect the development of atherosclerosis. [ Nature.com Link ] (£)
Nature Reviews
12/01/2016 at 17:00. Facebook
Nature Reviews Rheumatology: The endoplasmic reticulum (ER) is vital for cellular function and differentiation in every organ system. In this Review, the authors discuss how cells respond to ER stress and outline the ways that this stress can contribute towards rheumatic diseases. [ Nature.com Link ] (£)
Nature Reviews
12/01/2016 at 14:00. Facebook
Nature Reviews Cardiology: Microorganisms that populate the human body have been shown to be involved in metabolic and cardiovascular disorders, but the precise mechanisms are not completely understood. In this Review, Lindskog Jonsson and Bäckhed describe the different pathways by which the gut microbiota might affect the development of atherosclerosis. [ Nature.com Link ] (£)
Nature Reviews
12/01/2016 at 12:00. Facebook
Nature Reviews Neuroscience: Emerging evidence suggests that astrocytes may be as diverse in their physiological and functional characteristics as neurons. Ben Haim and Rowitch describe astrocyte heterogeneity, consider the mechanisms by which such diversity may arise and discuss the consequences of its disruption in disease. [ Nature.com Link ] (£)
Nature Reviews
11/30/2016 at 17:00. Facebook
Nature Reviews Gastroenterology and Hepatology: Obesity is a major public health problem worldwide, and bariatric surgery offers an effective option for treatment of obesity and related comorbidities. Here, Nguyen and Varela discuss the indications, safety and outcomes of different bariatric operations in obesity and related metabolic disorders, such as type 2 diabetes mellitus, and examine...
View details ⇨
Nature Reviews
11/30/2016 at 12:00. Facebook
Nature Reviews Molecular Cell Biology: Reversible mRNA methylation is an emerging mode of eukaryotic post-transcriptional gene regulation. N6-methyladenosine (m6A) affects mRNA processing, translation and decay during cell differentiation, embryonic development and stress responses. Other mRNA modifications — N1-methyladenosine (m1A), 5-methylcytosine (m5C) and pseudouridine — together with...
View details ⇨
Nature Reviews
11/29/2016 at 20:00. Facebook
Nature Reviews Urology: FOX transcription factors are differentially expressed in bladder cancer subtypes and some are key regulators of embryonic bladder development. Yamashita et al. describe the specific roles of FOX genes and proteins in development and differentiation, and highlight functions in bladder cancer pathogenesis. [ Nature.com Link ] (£)
Nature Reviews
11/29/2016 at 17:00. Facebook
Nature Reviews Clinical Oncology: A multidisciplinary approach is essential for the optimization of patient care in oncology, especially in the current landscape, in which standard-of-care approaches to cancer treatment are evolving towards highly targeted treatments, precise image guidance and personalized cancer therapy. Herein, the authors discuss current career development pathways for...
View details ⇨
Nature Reviews
11/29/2016 at 12:00. Facebook
Nature Reviews Immunology: Dendritic cells (DCs) shape tolerogenic and pro-inflammatory immune responses by presenting antigens to T cells; their ability to localize in peripheral tissues and secondary lymphoid organs is crucial for these functions. This Review describes the different migratory pathways employed by subsets of DCs from distinct tissue sites, detailing their mechanistic basis...
View details ⇨
Nature Reviews
11/28/2016 at 20:00. Facebook
Nature Reviews Disease Primers : Psoriasis is a chronic, immune-mediated disease that can severely affect patient quality of life. Various kinds of skin manifestations are possible; psoriatic arthritis is a common but underdiagnosed comorbidity. Treatments for psoriasis include topical agents, phototherapy and systemic and biologic agents. [ Nature.com Link ]
Nature Reviews
11/28/2016 at 17:00. Facebook
Nature Reviews Nephrology: Article series: Onconephrology - New data suggest that, in addition to mutations in tumour-suppressor genes, renal cancer is associated with epigenetic aberrations. Here, the authors discuss the mechanisms by which epigenetically silenced genes and mutations in genes that are involved in histone modification or chromatin remodelling dysregulate crucial cellular...
View details ⇨
Nature Reviews
11/28/2016 at 14:00. Facebook
Nature Reviews Genetics: A wealth of data is emerging from diverse studies of epigenomics, including genome-scale profiles of DNA methylation, histone modifications and higher-order chromatin features. In this Review, the authors discuss how, despite all this information, many challenges remain for inferring and proving the physiological and pathological functions of chromatin states. They...
View details ⇨
Nature Reviews
11/28/2016 at 12:00. Facebook
Nature Reviews Microbiology: Article series: Vector-borne diseases - In this Review, De Niz et al. discuss the contribution of key imaging tools to advances in our understanding of Plasmodium spp. biology and host–pathogen interactions over the past decade. These advances, pertaining to parasite structure and motility, as well as the liver and blood stages, have led to paradigm shifts in our...
View details ⇨
Nature Reviews Drug Discovery: Small-molecule drug discovery has traditionally focused on occupancy of a binding site that directly affects protein function. This article discusses emerging technologies, such as proteolysis-targeting chimaeras (PROTACs), that exploit cellular quality control machinery to selectively degrade target proteins, which could have advantages over traditional...
View details ⇨
Nature Reviews Endocrinology: Endocrine-disrupting chemicals (EDCs) can increase the risk of childhood diseases by disrupting hormone-mediated processes critical for growth and development. Here, Joseph Braun discusses epidemiological evidence of associations between early-life exposure to EDCs and childhood neurodevelopmental disorders and obesity. [ Nature.com Link ] (£)
Nature Reviews Neurology: Cryptococcal meningitis is a major cause of morbidity and mortality in immunocompromized individuals, and, even in apparently immunocompetent individuals, carries a high risk of mortality. Treatment in immunocompromized patients is challenging because these patients are at risk of immune reconstitution inflammatory syndrome (IRIS). This Review summarizes the diagnosis...
View details ⇨