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Nature Reviews Drug Discovery: Dysregulated autography is associated with a variety of conditions, including cancer, neurodegenerative diseases, cardiovascular disorders and infectious diseases. However, despite significant efforts, no specific modulators of autophagy have yet been moved into the clinic. Here, Galluzzi et al. discuss the therapeutic potential of autophagy modulators and...
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Nature Reviews Drug Discovery Dysregulated autography is associated with a variety of
Pavel Nesmiyanov
Robert Dziarmaga
Lorenzo Galluzzi
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yesterday at 16:00. Facebook
Nature Reviews Endocrinology: In this Review, Foulds et al. posit that endocrine-disrupting chemicals are an unappreciated driver of the development and progression of nonalcoholic fatty liver disease. Experimental animal studies supporting this association are discussed, together with the challenges of establishing a causal link in humans. [ Nature.com Link ] (£)
Nature Reviews Endocrinology In this Review Foulds et al posit that endocrinedisrupting
Perla Lopes
José Geovanni Romero Quintana
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Nature Reviews Neurology: Chronic pain presents a major health burden, affecting more than 20% of adults worldwide, but currently available analgesics lack efficacy and/or are associated with severe adverse effects. Here, Ellen Niederberger and colleagues discuss epigenetic modulation as a new opportunity in pain-relief therapy, and consider the future challenges for the clinical development...
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Nature Reviews Neurology Chronic pain presents a major health burden affecting more
Marcus Goncalves
Mila Voigt
Álefe Barbosa
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yesterday at 11:00. Facebook
Nature Reviews Cancer: This Perspective discusses some of the causes of the robustness and reproducibility problem in preclinical cancer research and suggests solutions. [ Nature.com Link ] (£)
Nature Reviews Cancer This Perspective discusses some of the causes of the
Haissa Oliveira Brito
Sayonara Lopez Sarzosa
Neftali Zavala
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05/25/2017 at 19:00. Facebook
Nature Reviews Disease Primers: Dental caries formation can affect individuals at any age and involves the interaction between the tooth, the microbial biofilm at the tooth surface and dietary sugars. This PrimeView, which accompanies the Primer by Pitts et al., focuses on the pathophysiology of dental caries formation. [ Nature.com Link ]
Nature Reviews Disease Primers Dental caries formation can affect individuals at any
Fabrizio Fai
Samantha Santinato
Hüseyin Örün
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05/25/2017 at 16:00. Facebook
Nature Reviews Rheumatology: The presence of antinuclear antibodies (ANAs) is an important criterion for the classification of autoimmune diseases such as systemic lupus erythematosus, but the specificity of ANA tests is controversial. This Perspectives article critically discusses the methods used in ANA testing for different diseases, as well as ways to improve the use of these assays in...
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Nature Reviews Rheumatology The presence of antinuclear antibodies ANAs is an important
Bianca Margareta Dumitrescu Sindilar
AnneCharlotte Mqt
Neftali Zavala
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05/25/2017 at 13:00. Facebook
Nature Reviews Cardiology: Cardiovascular disease (CVD) follows a seasonal pattern in many populations, often peaking after 'cold snaps'. In this Review, Stewart and colleagues identify the physiological and environmental factors that contribute to seasonality in nearly all forms of CVD, and describe the potential strategies that might attenuate peaks in cardiovascular events during cold and...
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Nature Reviews Cardiology Cardiovascular disease CVD follows a seasonal pattern in many
Meslioui Mounir
Rafaela Vale
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Nature Reviews
05/25/2017 at 11:00. Facebook
Nature Reviews Neuroscience: Cerebral blood flow regulation is essential for normal brain function. In this Review, Kisler and colleagues examine the cellular and molecular mechanisms that underlie cerebral blood flow regulation at the arteriole and capillary level, and how neurovascular dysfunction contributes to neurodegenerative disorders such as Alzheimer disease. [ Nature.com Link ] (£)
Nature Reviews Neuroscience Cerebral blood flow regulation is essential for normal brain
Tony Oceans
Raquel Castiglione
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05/24/2017 at 16:00. Facebook
Nature Reviews Gastroenterology and Hepatology: The clinical management of refractory eosinophilic oesophagitis (EoE) is challenging, owing to the limited data available to guide decision-making. In this Review, Dellon discusses the clinical definition of refractory EoE, examines the causes and predictors of non-response, and highlights both current and emerging treatment modalities for...
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Nature Reviews Gastroenterology and Hepatology The clinical management of refrac
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05/24/2017 at 13:00. Facebook
Medtech Dealmakers is a partnering supplement to Nature Biotechnology, Nature Medicine and Nature Reviews Drug Discovery, featuring the latest dealmaking opportunities and emerging technologies. Check out the latest issue for medtech dealmaking and financing trends in 2016, and diagnostics dealmaking from the past year- particularly in applications for immuno oncology. [ Nature.com Link ]
Medtech Dealmakers is a partnering supplement to Nature Biotechnology Nature Medicine and
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05/24/2017 at 11:00. Facebook
Nature Reviews Molecular Cell Biology: Nucleosome-remodelling complexes can slide or eject histones, or incorporate histone variants, but they share an ATPase–translocase 'motor' and a common DNA translocation mechanism. In a unifying 'hourglass' model of remodeller function, the different remodeller subfamilies use different modules for targeting to nucleosomes but converge on a DNA...
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Nature Reviews Molecular Cell Biology Nucleosomeremodelling complexes can slide
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05/23/2017 at 19:00. Facebook
Nature Reviews Urology: 3D organoids are valuable tools for increasing understanding of disease biology. In this Review, the authors describe how successful application of organoids into urological cancer research can further our understanding of these diseases and provide preclinical cancer models to aid precision medicine. [ Nature.com Link ] (£)
Nature Reviews Urology 3D organoids are valuable tools for increasing understanding of
Baraa Alqudah
Letícia Bueno
Naomi Richardson
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Nature Reviews
05/23/2017 at 16:00. Facebook
Nature Reviews Clinical Oncology: For three decades, the treatment of small-cell lung cancer (SCLC) has remained essentially unchanged, and patient outcomes remain dismal. In the past 5 years, however, advances in our understanding of the disease, at the molecular level, have resulted in the development of new therapeutic strategies, encompassing immunotherapies and novel molecularly targeted...
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Nature Reviews Clinical Oncology For three decades the treatment of smallcell lung
Cyrene Manansala
Raful Navarro
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05/23/2017 at 13:00. Facebook
Nature Reviews Materials: Heterostructuring and mixing of disparate materials provide new degrees of freedom to control carrier mobilities and exciton binding in solution-processed semiconductors. This Review highlights recent examples of heterostructured materials and devices, and examines the future direction of the field. [ Nature.com Link ] (£)
Nature Reviews Materials Heterostructuring and mixing of disparate materials pro
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05/23/2017 at 11:00. Facebook
Nature Reviews Immunology: In this Opinion article, the authors discuss our growing appreciation of antigen-inexperienced memory T cell subsets. They focus on the development and functions of the recently described 'virtual memory' and 'innate memory' CD8+ T cell populations, and propose a unified nomenclature for these subsets. [ Nature.com Link ] (£)
Nature Reviews Immunology In this Opinion article the authors discuss our growing
Kaniska Mukherjee
Jonathan Villanueva
Rysa Zaman
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05/22/2017 at 19:00. Facebook
Nature Reviews Disease Primers: PRIMER - Anaemia, thrombosis and smooth muscle dystonias are manifestations of paroxysmal nocturnal haemoglobinuria, a rare but potentially life-threatening haematological disorder. Inhibition of complement activation is the treatment of choice; stem cell transplantation is recommended for patients who also develop severe bone marrow failure. [ Nature.com Link ]
Nature Reviews Disease Primers PRIMER Anaemia thrombosis and smooth muscle dystonias are
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05/22/2017 at 16:00. Facebook
Nature Reviews Nephrology: The Oxford Classification of IgA nephropathy (IgAN) is the most widely accepted system for assessing histologic findings in IgAN. A new publication refines this classification by adding a crescent score, reassessing the segmental sclerosis score, and contextualizing the clinical relevance of the histologic lesions. [ Nature.com Link ] (£)
Nature Reviews Nephrology The Oxford Classification of IgA nephropathy IgAN is the
Anahid Gk
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05/22/2017 at 13:00. Facebook
Nature Reviews Genetics: A full understanding of chromatin in diverse cellular processes requires the consideration of its dynamics, but most standard chromatin assays provide only a static snapshot. This Review describes various emerging methods for probing chromatin dynamics across a wide range of temporal and spatial scales, and discusses the resulting biological insights. [ Nature.com Link...
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Nature Reviews Genetics A full understanding of chromatin in diverse cellular processes
Kaniska Mukherjee
Vania Marilande Ceccatto
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05/22/2017 at 11:00. Facebook
Nature Reviews Microbiology: The microbiota influences the development of cancer and the effect of cancer therapies. In this Review, the authors summarize the interactions between the microbiota, the immune system and tumours and how manipulation of the microbiota can be used therapeutically. [ Nature.com Link ] (£)
Nature Reviews Microbiology The microbiota influences the development of cancer and the
Terimar Moresco
Chien-Foung Huang
Michell Ruiz
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Nature Reviews
05/20/2017 at 13:00. Facebook
Nature Reviews Chemistry: Experienced practitioners often feel that studying chemistry was harder during their time at school, but is this really true? [ Nature.com Link ] (£)
Nature Reviews Chemistry Experienced practitioners often feel that studying chem