Nature Reviews
02/23/2017 at 12:00. Facebook
Nature Reviews Neuroscience: Impulsivity comes in various forms, with some forms considered more or less advantageous than others. Dalley and Robbins review the different types of impulsivity and their underlying neural mechanisms, and comment on the applicability of measures of impulsivity in research into psychiatric disorders. [ Nature.com Link ] (£)
Nature Reviews
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Nature Reviews Gastroenterology and Hepatology: Living donor liver transplantation is an underutilized transplant option outside of Asia for those with end-stage liver disease. Here, Fisher details the history of the procedure, its indications, contraindications and outcomes, and the criteria for selection of appropriate donors. [ Nature.com Link ] (£)
Nature Reviews
yesterday at 12:00. Facebook
Nature Reviews Molecular Cell Biology: The chemical modifications and structural features of mRNAs are highly dynamic. Together, they regulate the composition and function of the transcriptome by shaping RNA–protein interactions at different stages of the gene expression process. [ Nature.com Link ] (£)
Nature Reviews
02/21/2017 at 20:00. Facebook
Nature Reviews Urology: Intravesical immunotherapy using BCG is the treatment approach for patients with high-risk and intermediate-risk non-muscle-invasive bladder cancer (NMIBC). However, recurrence and progression are a problem. In this Review, an expert group of authors from the International Bladder Cancer Group discuss the treatment options available after BCG failure and provide...
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Nature Reviews
02/21/2017 at 17:00. Facebook
Nature Reviews Clinical Oncology: Data from the recent Stop 2G-TKI study confirm that around 60% of patients with chronic myeloid leukaemia who discontinue second-generation BCR–ABL1 tyrosine-kinase inhibitor (TKI) therapy after a sustained deep molecular response remain in remission for longer than 1 year. Importantly, the interim findings suggest that prior response to first-line TKI...
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Nature Reviews
02/21/2017 at 14:00. Facebook
Nature Reviews Materials: High pressure offers a unique degree of freedom for the creation of new materials, leading to new superconductors, superhard materials, high-energy-density materials and exotic chemical materials with unprecedented properties. This Review discusses these materials, along with recently developed theoretical and experimental methods for materials discovery at high...
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Nature Reviews
02/20/2017 at 20:00. Facebook
Nature Reviews Disease Primers : PRIMER Neuropathic pain is caused by a lesion or disease of the somatosensory system (including peripheral and central neurons). Here, the authors present the current descriptions of the presentation, causes, diagnosis and treatment of neuropathic pain with a focus on peripheral neuropathic pain, which has a greater knowledge base than central neuropathic pain....
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Nature Reviews
02/20/2017 at 17:00. Facebook
Nature Reviews Nephrology: Crystals can trigger different types of renal injury according to their speed at which they form and their localization. Here, the authors discuss shared and specific mechanisms underlying crystal formation and renal injury, such as regulated cell death and inflammasome activation. [ Nature.com Link ] (£)
Nature Reviews
02/20/2017 at 14:00. Facebook
Nature Reviews Genetics: Although it has been known for decades that RNA is subjected to numerous covalent modifications, there has been a recent surge in interest driven by sequencing-based transcriptome-wide detection methods and the realization that RNA modifications have important roles in diverse biological processes. This Review describes the range of detection strategies for RNA...
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Nature Reviews
02/20/2017 at 12:00. Facebook
Nature Reviews Microbiology: Circadian rhythms enable cells to anticipate cyclic changes in their environment. In this Review, Johnson et al. explore timekeeping systems that range from prototypical circadian clocks to hourglass timers and their role in different bacteria, including cyanobacteria and members of the microbiota. [ Nature.com Link ] (£)
Nature Reviews
02/17/2017 at 20:00. Facebook
Nature Reviews Drug Discovery: The B cell lymphoma 2 (BCL-2) family of proteins has a key role in regulating apoptosis and is often dysregulated in cancer. This has led to the development of several inhibitors of pro-survival BCL-2 family proteins such as BCL-2, BCL-XL and MCL1, including the BCL-2 inhibitor venetoclax, which has recently gained regulatory approval. Here, Ashkenazi and...
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Nature Reviews
02/17/2017 at 17:00. Facebook
Nature Reviews Endocrinology: Despite great interest in the role of irisin in glucose homeostasis, controversy still exists regarding the function, and even the existence, of this myokine. Here, Perakakis and colleagues provide an extensive evaluation of the evidence for the physiology and function of irisin from both animal and human studies. [ Nature.com Link ] (£)
Nature Reviews
02/17/2017 at 14:00. Facebook
Nature Reviews Neurology: Altered brain network connectivity might underlie the deficits in social cognition that characterize autism spectrum disorders (ASD). Here, Modi and Sahin discuss the use of event-related potentials (ERPs) evoked by sensory and social stimuli to assess network connectivity in humans with ASD and in animal models, and consider the potential for ERPs to provide a...
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Nature Reviews
02/17/2017 at 12:00. Facebook
Nature Reviews Cancer: Sumoylation is an important mechanism in cellular responses to stress, and appears to be upregulated in many cancers. This Review argues that sumoylation protects the stability and functionality of otherwise easily misregulated gene expression programmes and signalling pathways of cancer cells. [ Nature.com Link ] (£)
Nature Reviews
02/16/2017 at 20:00. Facebook
Nature Reviews Disease Primers: This PrimeView highlights how a diagnosis of neuropathic pain is reached, which is important to provide appropriate treatments. [ Nature.com Link ]
Nature Reviews
02/16/2017 at 17:00. Facebook
Nature Reviews Rheumatology: Ectopic lymphoid structures have been identified in the target organs of a subset of patients with rheumatic autoimmune diseases. This Review describes these structures and summarizes our current understanding of how they form, function and contribute to autoimmunity. [ Nature.com Link ] (£)
Nature Reviews
02/16/2017 at 14:00. Facebook
Nature Reviews Cardiology: Natural killer T (NKT) cells can be activated by both endogenous and exogenous lipid antigens. In this Review, Getz and Reardon provide an overview of NKT cells in the immune system, and propose mechanisms by which NKT cells can promote atherosclerosis. [ Nature.com Link ] (£)
Nature Reviews
02/16/2017 at 12:00. Facebook
Nature Reviews Neuroscience: Lewy pathology (LP) and neuronal death in clinical Parkinson disease (cPD) have been attributed to the simple spread of misfolded α-synuclein. Surmeier et al. show that the pattern of pathology in cPD is not consistent with this simple model, suggesting that cell-autonomous factors also contribute to pathogenesis. [ Nature.com Link ] (£)
Nature Reviews Chemistry: Experienced chemists know that chemistry is all around them. Helping students to see the connections between real life and concepts of organic chemistry is the driving force behind the development of a set of online resources pioneered at UCLA. [ Nature.com Link ]
Nature Reviews Urology is proud to present the Movember Collection in partnership with the Movember Foundation. The collection is based around themes from the Global Action Plan (GAP) - a worldwide collaboration between researchers in prostate and testicular cancer, funded by Movember. Launched in 2011, the scheme connects researchers around the globe, improving data and knowledge sharing, and...
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