In a new Perspective Audio Interview, Stuart Slavin discusses depression and suicide among physicians and trainees and how to address stigma associated with mental illness. Listen to the latest podcast, “Depression and Suicidality in Medicine,” now: [ Nej.md Link ]

Kathryn — NEJM

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Answer to yesterday’s #MedEd Quiz:

Which one of the following statements describing withdrawal treatment for patients with benzodiazepine dependence is true?
A. Cognitive behavioral therapy has a limited role.
B. Concurrent opioid detoxification is recommended.
C. Switching from a benzodiazepine with a short half-life to one with a longer half-life is associated with a better outcome.
D. The...
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Treatment of Benzodiazepine Dependence | NEJM Resident 360

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The American Health Care Act would make insurance less affordable for low-income Americans, increase the uninsured population, and take vast funds away from states. Rather than repealing and replacing the Affordable Care Act, the GOP plan offers only a mirage of reform. Read the new Perspective article by Jonathan Oberlander, Ph.D. [ Nej.md Link ]

The Mirage of Reform — Republicans’ Struggle to Dismantle Obamacare — NEJM

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#MedEd Quiz:

Which one of the following statements describing withdrawal treatment for patients with benzodiazepine dependence is true?
A. Cognitive behavioral therapy has a limited role.
B. Concurrent opioid detoxification is recommended.
C. Switching from a benzodiazepine with a short half-life to one with a longer half-life is associated with a better outcome.
D. The use of several...
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Treatment of Benzodiazepine Dependence | NEJM Resident 360

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Long-term use of benzodiazepines can lead to dependence. Symptoms of withdrawal include anxiety, irritability, confusion, seizures, and sleep disorders. Withdrawal management relies on the use of a single agent (diazepam) and gradual dose reduction. NEJM Resident 360 has Clinical Pearls, Morning Report Questions, and free access to the article. [ Nej.md Link ]

Treatment of Benzodiazepine Dependence | NEJM Resident 360

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Sounding Board: Advantages of a Truly Open-Access Data-Sharing Model. There are many models for sharing clinical-trial data. These investigators provide their viewpoint on why an open-data model has value over others. [ Nej.md Link ]

Advantages of a Truly Open-Access Data-Sharing Model — NEJM

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An 86-year-old woman with a history of tuberculosis presented with symptoms of epigastric and chest pain. A dense opacity in the upper left lung was suggestive of an oleothorax. [ Nej.md Link ]

Incidental Finding of Oleothorax — NEJM

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This week’s From Pages to Practice post on NEJM Resident 360 looks at pregabalin for sciatic pain. In a randomized trial involving patients with sciatica, the antiepileptic drug pregabalin, at a dose of up to 600 mg per day, was no more effective than placebo in reducing pain or disability over the course of 8 weeks and resulted in a higher incidence of adverse events. Click through for free...
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A PRECISE Study of Pregabalin for Sciatica | NEJM Resident 360

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Through his own recovery, a physician with a history of depression, suicidal ideation, and alcoholism has learned important lessons for the medical community — about self-care, stereotyping, stigma, vulnerability, professionalism, patient safety, and support. Read "Breaking the Stigma — A Physician’s Perspective on Self-Care and Recovery" by Adam B. Hill, M.D. [ Nej.md Link ]

Breaking the Stigma — A Physician’s Perspective on Self-Care and Recovery — NEJM

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Last August, a fourth-year medical student ended her life by jumping out of a window. In the aftermath, other students expressed rage over not feeling adequately supported, indicating that they were also struggling with depression, anxiety, and suicidal ideation. Read the Perspective article, "Kathryn," by David Muller, M.D. [ Nej.md Link ]

Kathryn — NEJM

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An interview with a team from Boston University who placed in the SPRINT Data Analysis Challenge. See the presentation on Monday, April 3, at the #NEJMDataSummit. Register now for this free, live web event! [ Events.nejm.org Link ] #meded
Images in Clinical Medicine: A 46-year-old man with uncontrolled type 2 diabetes and alcoholic liver disease presented with painful swelling in his scrotum and perianal region; physical examination was notable for necrotic-appearing tissue in both areas. [ Nej.md Link ]

NEJM | Fournier’s Gangrene

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Sub-Saharan Africa has the highest rate of death associated with rotavirus. Current oral rotavirus vaccines require refrigeration, which makes transportation and storage challenging. Is there a low-cost, heat-stable alternative? New research findings are summarized in this short video. Full study: [ Nej.md Link ]

Watch more Quick Take videos: [ Nej.md Link ]
A 46-year-old woman who had recently returned from a trip to the Ivory Coast presented to the emergency department with a 10-day history of pain and swelling in her right arm. What is the diagnosis? Take the new Image Challenge now! [ Nej.md Link ]

NEJM - Image Challenge

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Join your peers for this week’s NEJM Group Open Forum as we discuss the recently published Original Article, “Trial of Pregabalin for Acute and Chronic Sciatica.” The authors of this study are discussing the trial results and taking questions. Join the discussion! [ Nej.md Link ]

@NEJM Ask the Authors & Experts: Topic in Pain Management • NEJM Group Open Forum • Medstro

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As part of the Changing Face of Clinical Trials series, Steven R. Cummings, M.D., co-authored a Review Article in which electronic informed consent and Internet-based trials are summarized. In this video, Dr. Cummings gives a brief overview and an example of an Internet-based trial. Full article: [ Nej.md Link ]
NEJM Journal Watch’s Paul Sax rewrites Tom Price’s vaccine interview with Wolf Blitzer. See if you like it more than -- or less than -- the original.

What Health and Human Services Secretary Tom Price Should Be Saying About Required Immunizations - HIV and ID Observations

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NEJM Journal Watch blogger Harrison Reed argues that talented jerks -- even superstars -- have no place in healthcare settings or other workplaces. Do you agree?

Toxic Talent: Why High-Performing Jerks Aren't Worth the Trouble - In Practice Blog

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Answer to yesterday’s #MedEd Quiz:

According to U.S. guidelines, when should antiretroviral therapy for newly diagnosed HIV begin in patients with cryptococcal meningitis?
A. Simultaneously with the initiation of antifungal therapy.
B. Seventy-two hours after the initiation of antifungal therapy.
C. One week after the initiation of antifungal therapy.
D. Four to 6 weeks after the initiation...
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A Zimbabwean Man with a Headache | NEJM Resident 360

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Join us for "Aligning Incentives for Sharing Clinical Trial Data," a free web event on April 3-4, 2017. Take part in an open conversation among clinical trial stakeholders to help identify sustainable solutions for responsible sharing of data. Register now: [ Events.nejm.org Link ]