Watch Jeffrey M. Drazen, M.D., Editor-in-Chief of NEJM, discuss how research funding may be affected by the 21st Century Cures Act. Dr. Drazen spoke earlier today at The Forum at Harvard T.H. Chan School of Public Health.
#MedEd Quiz:

Which one of the following statements about screening for Chlamydia trachomatis is true?
A. A first-catch urine specimen may fail to detect up to 10% of infections.
B. Culture remains the preferred diagnostic test for C. trachomatis.
C. Endocervical swabs are uniformly preferred over endovaginal swabs collected by the woman herself for screening tests.
D. Screening should be...
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Screening for Chlamydia trachomatis Infections | NEJM Resident 360

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Chlamydial infection may result in pelvic inflammatory disease, infertility, and ectopic pregnancy. Chlamydia screening is recommended in sexually active women younger than 25 years of age and other women at increased risk and can be performed on vaginal swabs or urine samples. NEJM Resident 360 has Clinical Pearls, Morning Report Questions, and free access to the article. [ Nej.md Link ]

Screening for Chlamydia trachomatis Infections | NEJM Resident 360

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In new perspective audio interview titled "Cannabis Legalization," RAND Corporation Co-Director Beau Kilmer, Ph.D., discusses the effects of cannabis on health and how jurisdictions can minimize harms related to its legalization. [ Nej.md Link ]

Recreational Cannabis — Minimizing the Health Risks from Legalization — NEJM

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Answer to yesterday’s #MedEd Quiz:

Which one of the following statements about adverse events considered to be treatment-related by trial investigators is true?
A. The most common treatment-related adverse events were injection-site pain and headache.
B. Rates were significantly higher with lanadelumab than with placebo.
C. There was one patient who discontinued lanadelumab owing to a...
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Hereditary Angioedema Prophylaxis | NEJM Resident 360

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#MedEd Quiz:

Which one of the following statements about adverse events considered to be treatment-related by trial investigators is true?
A. The most common treatment-related adverse events were injection-site pain and headache.
B. Rates were significantly higher with lanadelumab than with placebo.
C. There was one patient who discontinued lanadelumab owing to a treatment-related adverse...
View details ⇨

Hereditary Angioedema Prophylaxis | NEJM Resident 360

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In patients with hereditary angioedema with C1 inhibitor deficiency, swelling episodes are related to the release of bradykinin from high-molecular-weight kininogen from kallikrein action. Lanadelumab, which inhibits kallikrein action, reduced the rate of attacks of angioedema. NEJM Resident 360 has Clinical Pearls, Morning Report Questions, and free access to the article. [ Nej.md Link ]

Hereditary Angioedema Prophylaxis | NEJM Resident 360

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Recent legislation promotes the development of formulations for children of medications usually taken by adults. However, these new liquid dosage forms have sharply increased costs, as compared with the tablet forms sold for adults. [ Nej.md Link ]

Pediatric Drug Formulations — Unintended Consequences of Legislation — NEJM

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The emergence of artemisinin resistance in Plasmodium falciparum has threatened the effectiveness of malaria treatment in Southeast Asia. In this report, such resistance has been observed in a patient who was working in Equatorial Guinea. [ Nej.md Link ]

Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa — NEJM

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Images in Clinical Medicine: Empyema Necessitatis. A 40-year-old man presented with fever, weight loss, dyspnea, and cough. Physical examination revealed a tender, bulging anterior thoracic mass. [ Nej.md Link ]

The New England Journal of Medicine

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This week’s From Pages to Practice post on NEJM Resident 360 looks at MRI risks for patients with a pacemaker or ICD. A total of 1500 nonthoracic MRI examinations were performed on patients with a non–MRI-conditional pacemaker or ICD, after programming of the devices in accordance with a standardized protocol. No patient whose device was appropriately programmed had device or lead failure....
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Is MRI Safe for Patients with Cardiac Devices? | NEJM Resident 360

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Join your peers on NEJM Resident 360 for a discussion on political activism and physician advocacy. Maybe you’ve seen someone who started a community clinic to meet a gap in the service or successfully lobbied on Capitol Hill. You want to know where to start and what skills you need to become a physician advocate. In this discussion, experts share their personal stories and highlight skills...
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NEJM Resident 360 | Seeking a Better Society: Political Activism and Physician Advocacy

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The Conference on Retroviruses and Opportunistic Infections (CROI) returned to Seattle last week for its 24th meeting. Dr. Paul Sax offers his take on the most interesting studies (with helpful links to the abstracts!) in his latest blog post for NEJM Journal Watch.

Really Rapid Review — CROI 2017, Seattle - HIV and ID Observations

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President Donald J. Trump cannot repeal the Affordable Care Act by executive order. So what can actually be changed by the administration, and how likely — or desirable, even to congressional Republicans — are those and other changes? [ Nej.md Link ]

NEJM | Trump’s Executive Order on Health Care— Can It Undermine the ACA if Congress Fails to Act?

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Twenty percent of the U.S. population now lives in states that have passed ballot initiatives to allow #cannabis to be sold for recreational use. The net effect of cannabis legalization on public health is uncertain, and much will depend on how the laws are implemented. Get the full perspective article and audio interview with RAND Corporation Co-Director Beau Kilmer, Ph.D.: [ Nej.md Link ]

NEJM | Recreational Cannabis — Minimizing the Health Risks from Legalization

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A 5-year-old boy presented with nausea, vomiting, and intermittent abdominal pain. Images showed giant cerebriform enlargement of rugal folds in the fundus and the body, which were suggestive of Ménétrier’s disease. [ Nej.md Link ]

NEJM | Gastric Gyri — Pediatric Ménétrier’s Disease

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Patients with hereditary angioedema with C1 inhibitor deficiency may have recurrent, unpredictable swelling episodes that require immediate treatment, but current options are limited by side effects. Is there a safe and effective therapy? New research findings are summarized in this short video. Full study: [ Nej.md Link ]

View more Quick Take videos: [ Nej.md Link ]
A 67-year-old man with a significant cardiac history and renal disease presented to the emergency department with neck swelling, dysphagia, and hoarseness. Computed tomography scans of his neck demonstrated these findings. What is the diagnosis? Take the new Image Challenge now! [ Nej.md Link ]

NEJM - Image Challenge

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In 2016, important research on racial disparities in end-of-life care was published. Join our expert panel in discussing the newest data on this old problem and how to manage this issue. [ Nej.md Link ]

NEJM Journal Watch 2016 Year in Review – Racial Disparities in End-of-Life Care • NEJM Group Open Forum • Medstro

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In NEJM Journal Watch Pediatrics and Adolescent Medicine, Dr. Robin Steinhorn reviews a recent NEJM study on outcomes among infants born at 22-24 weeks’ gestation.

The Frontier of Neonatology: The Limits of Viability

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